LRG News

Fri, 2016-09-16

A re-design of the LRG website is underway. Stay tuned for more!

Thu, 2014-08-28

All LRG records have now been corrected to contain the LRG creation date and not the RefSeqGene creation date.  The rest of the record remains unchanged. We apologize for any incovenience this might have caused.

Tue, 2014-05-20

The LRG Project has now made over 500 LRGs public.  These records have been created specifically for the reporting of variants at genes with clinical implications. They contain stable reference sequences as well as additional information that reflects the most up-to-date biological knowledge on these genes. The use of LRGs has been recommended by the Human Genome...

Wed, 2014-05-07
The updatable section of each LRG has now been regenerated to contain the most up-to-date information available from NCBI and Ensembl (Ensembl release 75, GRCh37 primary assembly) for the given LRG region. The fixed section remains unchanged. It is our goal to update the updatable section twice a year. The next update will take place in October 2014. 
Mon, 2014-04-14

LRG regions and transcripts are now available to view in the UCSC Genome Browser. The “LRG Regions” track is in the “Mapping and Sequencing” group, while the “LRG Transcripts” track is in the “Genes and Gene Predictions” group. Searching using an LRG accession number is also supported and will return all LRG transcripts for that specific accession.

Thu, 2014-02-13

A new publication from the LRG team has recently been published in the Nucleic Acids Research 2014 Database Issue

Locus Reference Genomic: reference sequences for the reporting of clinically relevant sequence variants, Macarthur JA et al., Nucleic Acids Res. 2014 Jan (doi: 10.1093/nar/gkt1198)


Wed, 2013-10-02

Schema Updates

All LRG records have been updated to a new XML schema (schema 1.8). The new records are available on the LRG website and on the FTP site (

The main changes to the schema are:

  • The inclusion of a ...
Wed, 2013-05-08

All LRG records have been regenerated with the updatable section now containing the most up to date information available from NCBI and Ensembl (Ensembl release 71). We are planning to update the updatable section of all LRGs twice a year, in April and October.

Thu, 2012-08-02

All LRG records are now available in an updated XML schema (schema 1.7). The schema 1.7 records are now viewable on the LRG website and on the ftp site (


The main change to the new schema is the inclusion of mapping information...

Thu, 2012-08-02

We have now launched a “News” page on the LRG website ( In addition to any LRG news items an update will also be posted once a month giving details of all LRGs requested, created or made public in the previous month. These news items can also be received by e-mail. To subscribe please send an e-mail to ...