LRGs are created upon request by collaborators (members of diagnostic and research communities).
Before requesting an LRG
Make your request
Feel free to contact us with any pre-request enquiries, especially if you are planning to request multiple LRGs.
Email us at firstname.lastname@example.org to make your request and include the following details. If you are requesting multiple LRGs please provide the information in a spreadsheet format.
The LRG record may include more than one transcript, if required for reporting variants. Please list the more commonly used transcript first (e.g. t1 = NM_x, t2= NM_y).
Requesters may suggest any transcript of choice (RefSeq or ENST) for inclusion in an LRG record. Ultimately, the transcript sequences included in the LRG records are identical to RefSeq transcripts (NM). If there is no RefSeq transcript for your transcript of interest, LRG curators will work with the NCBI to create it.
If you do not know what transcripts should be included in the record please note this in your email. LRG curators will work with you to establish which transcript is most appropriate.
The genomic sequence included in each LRG record is identical to the RefSeqGene sequence (RSG) for the gene of interest.
If there is no RSG for the gene, LRG curators will work with the NCBI to create it.
If there is an issue with the RSG, mention this in your email and LRG curators will work with yourself and the NCBI to resolve the issue.
Community information section
A “Community Section” is included in LRG records to note additional information deemed relevant by the requesters.
This section may include: